Phosphoproteins Iii . Increase in Phosphorylation during Histone - Phosphoprotein Interaction 739

نویسنده

  • P. B. KAPLOWITZ
چکیده

The effects of histones on the enzymatic phosphorylation of nuclear phosphoproteins have been extensively studied in vitro. Histones cause a 5to Io-fold increase in the rate and extent of phosphorylation of nuclear phosphoprotein, with the lysinerich histones being the most effective at stimulation. Evidence suggests that the histones are not being phosphorylated themselves, but rather act to make more sites available for phosphorylation in the phosphoprotein itself. The possible physiological significance of histone-phosphoprotein interactions is discussed.

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تاریخ انتشار 2002